MicroRNA therapy, which emerged as an experimental treatment in the early 2000s, is based on regulating gene expression by interacting small RNAs with microRNA targets. This approach has already been used in treating chronic skin ulcers and hypertrophic scars and, in recent years, has been actively investigated in the context of acne. Our post describes how close we came to putting this method into practice.

Pilonidal disease is an inflammatory condition involving the formation of cysts or fistulas in the area of the intergluteal cleft due to inflammation of the hair follicles. It is often accompanied by pain and infection and may require surgical intervention. Standard therapy, consisting of hygiene, special creams, and mechanical depilation, can reduce the severity of the disease but cure it completely. The hope for patients has become laser hair removal. How it helps in solving this problem is described in our new post.

Rosacea is a chronic inflammatory skin disease that develops due to dysregulation of the microcirculation in the midface. The clinical manifestations of rosacea are erythema and a progressive inflammatory rash. Despite its prevalence (according to various estimates, rosacea affects up to 22% of the population), this dermatosis still needs to be fully understood, and standard treatments are only sometimes effective. Research in recent years has drawn attention to tranexamic acid, known for its effects on melasma and post-inflammatory hyperpigmentation, to combat rosacea symptoms. These studies are described in our new post.

Trichotillomania (TTM) is a psychiatric disorder characterized by frequent, recurrent, and irresistible urges to pull hair from one's head, eyebrows, or other areas of the body. Cognitive behavioral therapy and antidepressants have traditionally been used to treat this disorder, but these treatments are not always successful. In recent years, research has emerged that looks at the use of injectable botulinum therapy in TTM patients. For details, see our new post.

Retinoids such as retinol and retinoic acid are widely used in anti-aging therapy because they stimulate cell renewal, collagen synthesis, and wrinkle elimination. However, their use is limited due to pronounced adverse reactions such as redness, dryness, flaking, and skin irritation, which are especially noticeable in people with sensitive skin. The search for safe alternatives with retinol-like effects remains an urgent task. Promising retinol substitutes include bakuchiol and Vigna aconitifolia bean extract. More about the retinol plant analogs study is in our post.

Why does hair turn gray, and can it be stopped? A new study has discovered a mysterious process that leads to hair color loss: when a person reaches a certain age, the melanocyte progenitor stem cells responsible for pigmentation get “stuck” in a transitional state and lose their function. What if this could be reversed? Scientists believe that by unlocking the secret of these “chameleon cells,” we can understand why we are graying and learn how to prevent graying. For details see our new post.

A balanced skin microbiome is one of the guarantors of skin health. Changes in the species composition of the microbiome may be one of the links in the pathogenesis of skin diseases or a consequence of them. For this reason, the skin microbiome is considered by many researchers and clinicians as one of the therapeutic targets that can be used to improve the health and aesthetic appeal of the skin. In our new post, we will discuss the effects of blue light on the skin microbiome composition of atopic patients and the prospects of its application for phototherapy of atopic dermatitis.

Green hair color indicates not only the boldness of the personality. In some cases, green hair coloration is a symptom of a disease called chlorotrichosis. The first cases of chlorotrichosis were described in 1654. At that time, the owners of "green hair" were copper workers engaged in copper processing. Today's chlorotrichosis patients are hapless pool-goers. What does copper have to do with it? How to avoid chlorotrichosis? Find out in our post.

Due to the secretions of eccrine, apocrine, and sebaceous glands, the axillae provide a moist and nutrient-rich habitat for many microorganisms. The appearance of odorless sweat is caused by the biotransformation of naturally occurring odorless secretions into volatile odorous molecules. In our new post, you will learn how the underarm microbiome changes during laser hair removal and how this affects the severity of sweat odor.

Living in a multinational world, we see the beauty of the human image in all its diversity. The combination of phenotypic traits endows each ethnic group with recognizable appearance features. As research shows, this also hides the skin's significant structural and functional features. Is it true that dark skin has more pronounced barrier properties, while light skin is drier and more fragile? This question has seriously interested scientists from Switzerland.

Hirsutism is an excessive growth of hair of the male type in women: lightly colored pubes transform into thick and pigmented terminal hairs above the upper lip, on the chin, in the sideburns, as well as on larger areas of the body — the lower abdomen, inner thighs, nipples, sternum, sacrum, and shoulders. Pathological hair loss is caused by diseases associated with hyperandrogenism or increased sensitivity of androgen receptors, which significantly complicates the long-term elimination of unwanted hair. Will the laser cope with this target? What does the effectiveness of laser hair removal for hirsutism depend on? You will find the answers in our new post.

Functional food is a powerful therapeutic tool that can be used to prevent and correct age-related skin changes. Functional foods offer health benefits beyond their nutritional value and positively impact health due to the high potency of their active ingredients. A wide range of functional foods of plant origin that, when consumed in the right amounts regularly, can reduce the signs of photoaging. In our new publication, you will learn about three vegetable products with the most impressive scientific evidence base — mango, almond, and avocado.

Unwanted hair is a significant aesthetic defect that is normal from the physiology point of view but can be perceived by the patient as a problem. The subjective factor — the beauty standards accepted in a particular society and the patient's psychological characteristics — play a decisive role in the attitude toward the problem of unwanted hair and the need for its elimination. However, in some cases, excessive hair growth is a warning sign indicating diseases. In our new post, you will learn about the different forms of excess hair growth and their causes.

Morbihan disease is a rare condition of unknown etiology characterized by persistent, dense, non-pitting erythematous swelling of the middle and upper third of the face. Morbihan disease is sometimes categorized as a special form of rosacea and is not amenable to traditional rosacea therapy. In July 2023, a clinical case study published in the Journal of Clinical, Cosmetic and Investigational Dermatology published an effective treatment for Morbihan disease using macrofocused high-intensity focus ultrasound (MF-HIFU) that significantly reduced swelling and erythema and decreased pain. Read more in our new post.

When looking for skin health, we are often faced with choosing between a variety of different dietary systems.  One such system is the vegan diet.  By eliminating all animal products — meat, fish, dairy, eggs, and even honey —a vegan diet relies solely on plant-based food sources. As a result, a very specific composition of nutrients is delivered to the body, which can significantly affect the skin's condition — both healthy and pathologic. In this context, the relationship between nutrition and dermatologic pathologies is particularly relevant. In this post, we will examine the relationship between vegan diet and psoriasis, one of the most common dermatologic diseases.

The discovery of niacinamide's potential in 1938, when researchers found its ability to cure pellagra in dogs, was a milestone in medical science. Since then, niacinamide, administered in doses far more than its vitamin requirement, has been used to treat many diseases and conditions, from protecting neurons and vascular cells from ischemic damage to preventing neurological disorders such as depression, Alzheimer's and Parkinson's diseases. In recent years, niacinamide has taken a leading position in modern dermatology. Known for its anti-aging and anti-inflammatory properties, this vitamin B3 derivative has become a popular ingredient in cosmetic products to improve skin health. However, as with many bioactive substances, niacinamide has its complexities and potential risks, especially when used in high dosages. The surprising and unexpected unwanted effects of niacinamide are discussed in our new post.

When we wish our loved ones a Happy New Year, we always wish them good health. One of the available measures to maintain or improve health is taking vitamins. The impact of vitamin deficiency on the body can sometimes be catastrophic and even life-threatening. One of the most "deficient" vitamins today is vitamin A. In 20% of the population of the developed world, the concentration of vitamin A in blood plasma and liver is below the norm. The consequences of vitamin A deficiency for the skin are the epidermal barrier weakening, decreased regenerative capacity of the skin, accelerated aging, decreased skin immunity, aggravation of chronic inflammatory diseases, hyperkeratosis, scaling, and itching. Since foods contain many nutrients and other health benefits, vitamin A needs should be met primarily through them. In our post, you will find recommendations on how to find the best food sources of vitamin A.

Vitamin A and its derivatives are among the top substances in modern skincare products. They are credited with many effects: wrinkle smoothing and improved healing, pigmentation reduction and sebum reduction, skin lifting, and even hair growth stimulation. Are these substances effective at solving such different problems? Let's put it this way: vitamin A has many different clinical effects, but they are all predominantly related to its ability to regulate the cell cycle, primarily cell division. In this regard, the most sensitive to retinol are the rapidly dividing cells, including keratinocytes and sebocytes in the skin. As for other members of the skin cell community, such as immunocytes and melanocytes, it is not so obvious since these cells are present in the skin in a mature state. The latest research on the effects of vitamin A on melanocytes is described in our editorial article.

Rosacea is a common inflammatory skin condition. The severity of symptoms can depend on many external and internal factors, including nutrition. Certain foods are known to worsen rosacea symptoms, but publications on this topic are often contradictory. To clarify this issue, scientists from the UK have analyzed the available publications on the influence of drinks and foods on the rosacea manifestation. More about this — in the News and Reviews on our website.

Physical plasma-based methods have occupied a unique niche in medicine. They are used for tissue removal (plasma sublimator or plasma scalpel), for wound non-contact sterilization (including purulent wounds), and more recently for skincare due to their stimulating effect. Cosmetic plasma biostimulators use air as a gas source. The air is ionized by a dielectric barrier discharge (DBD) in the air gap between the dielectric layer insulating the electrode and the skin (ground). This produces numerous thin, luminous "jets" like water jets in a shower. This external similarity was the basis for the name of such devices — plasma shower. The essence of the plasma shower is described in our editorial note.

Recently, vitamin D has been constantly in the rumor. There are more and more scientific publications on the relationship of low levels of active vitamin D metabolites with the development of infectious, cardiovascular, chronic inflammatory, allergic, autoimmune, and cancer diseases. It may seem that vitamin D is relegated to the role of a panacea for all diseases. We have tried to address the narrower issue of vitamin D's impact on melanoma incidence and the course of this dangerous disease.

Lack of or poor sleep quality has become a characteristic of modern man. Often, late bedtimes, insufficient sleep duration, and smartphone use before bedtime become bad habits that start in childhood. The negative impact of lack of sleep on the functioning of the nervous system is a well-known fact that does not require discussion. However, it is worth remembering that complex signaling pathways connect the nervous system with all organs. One of the most active participants of such bidirectional communication is the skin. Our new article is devoted to the effect of lack of sleep on skin condition.

Neurogenic inflammation is a pathological process based on bidirectional interactions between cells of the nervous and immune systems involving a wide range of biologically active substances. It is a common link between chronic inflammatory diseases and pathologic skin conditions such as psoriasis, atopic dermatitis, rosacea, and sensitive skin. Our post reviews research findings on the role of neurogenic inflammation in rosacea pathogenesis.