Glycation is a key mechanism of skin aging, in which advanced glycation end products (AGEs) degrade collagen, trigger inflammation, and induce oxidative stress. Natural polyphenols can counteract this process, with hydroxytyrosol—a potent antioxidant from olives—deserving special attention. Researchers at Peking University investigated whether hydroxytyrosol could protect the skin from accelerated aging caused by a high-AGE diet. The mouse model experiment showed that a high dose of the compound restored skin moisture, epidermal and dermal thickness, increased hydroxyproline levels (a collagen marker), normalized antioxidant enzyme activity, and reduced proinflammatory cytokines. A separate discovery was its effect on the intestinal barrier: it restored tight junction protein expression, highlighting the role of the gut-skin axis in its protective action. Full details and practical takeaways—in our editorial review.

In February 2026, the International Journal of Molecular Sciences published a review on mitochondria-targeted biophysical priming of autologous biologics for skin regeneration and wound repair. At first glance, this may seem far removed from everyday aesthetic practice. In fact, it speaks directly to issues skincare specialists face every day: photoaging, loss of firmness, wrinkles, and slower tissue recovery. The authors propose a new way to think about autologous materials: their clinical value may depend not only on their contents but also on mitochondrial function. In this feature, we explore why this matters for anti-aging practice and which physical conditioning methods are currently considered the most promising. A closer look at the study and its practical implications is available in our editorial note.

Biofilms remain a major cause of chronic wounds and antimicrobial treatment failure: bacteria within these structures are protected by an extracellular matrix, exhibit metabolic heterogeneity, and can demonstrate resistance levels far exceeding those of planktonic cells. In this context, membrane-active antimicrobials—including peptides, peptidomimetics, polyphenols, and other compounds—are attracting growing interest due to their ability to disrupt bacterial membranes, interfere with cell-to-cell communication, and weaken biofilm structure. A recent review examines both these molecules and pharmaceutical strategies that improve their stability and efficacy in topical delivery systems. Full breakdown in our editorial note.

The combination of hyaluronic acid with amino acids is one of the most discussed trends in modern biorevitalization. A new 2026 meta-analysis summarizes a decade of clinical experience with these formulations, providing objective data on how the addition of glycine, proline, and lysine affects wrinkle depth, dermal thickness, and epidermal growth factor (EGF) expression. The article examines histological results confirming the biostimulatory potential of these products, alongside methodological limitations of the evidence base, including the issue of "extreme heterogeneity." This analysis evaluates how the diversity of formulas and protocols impacts the predictability of aesthetic outcomes in clinical practice. See details in our editorial note.

  New goals for cross-linked hyaluronic acid application The understanding of hyaluronic acid's potential in aesthetic medicine has expanded significantly. While cross-linked hyaluronic acid was previously associated primarily with volume restoration and the correction of deep folds, today more attention is being paid to its impact on skin quality. This concept encompasses a combination of characteristics, including hydration, microrelief smoothness, pore visibility, and the overall visual perception of the skin surface. This is the core idea behind the study under discussion [1]. The authors questioned whether low-cross-linked hyaluronic acid fillers could be used not only for volumization but also to improve skin quality, specifically to reduce the appearance of enlarged pores. To investigate this, the study compared two products: a cohesive polydensified matrix hyaluronic acid (20.0 mg/mL) and a similar formula additionally containing glycerol (17.5 mg/mL). The choice of glycerol was based on its properties as a humectant; earl...

Skin aging is traditionally viewed through the lens of aesthetic changes; however, in 2007, the term "dermatoporosis" was proposed to describe a syndrome of chronic cutaneous insufficiency and fragility [1]. This condition goes beyond cosmetic defects and represents a serious medical problem associated with the loss of skin protective functions. Topical application of retinaldehyde and intermediate-size hyaluronate fragments (50–400 kDa) significantly reduced the number of p16Ink4a-positive senescent cells in the epidermis and dermis of dermatoporosis patients, leading to significant clinical improvement. Full breakdown — in our editorial note on the website.

Vitiligo is often viewed as an autoimmune skin disorder, and some patients have antinuclear antibodies (ANA) on lab testing. But does ANA positivity mean phototherapy will work less well—or carry higher risks? In a prospective cohort study published in the Journal of Dermatological Treatment in early 2026, researchers examined whether ANA status affects the effectiveness and tolerability of 308-nm excimer light therapy for vitiligo when combined with topical agents (and, in highly active disease, oral prednisone mini-pulse therapy). Here is how the groups differed, which areas repigmented differently, and why the authors suggest that low-titer ANA usually does not require changing standard management. Full analysis and practical takeaways in our editorial note.

  The link between sleep and skin condition is increasingly being discussed, but in trichology this factor has long remained in a secondary role. Meanwhile, sleep disturbances potentially affect several systems important for the hair follicle: inflammatory and immune regulation, stress response, and circadian rhythms. The authors of a systematic review published in Dermatology and Therapy (Heidelberg) in November 2025 collected and summarized data on how sleep problems are associated with different variants of hair loss — from alopecia areata and androgenetic alopecia to telogen effluvium and scarring forms [1].   How the study was organized The work was conducted as a systematic review according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)—an international reporting standard for systematic reviews. The authors searched PubMed and Scopus (October 2025) for publications without date or language restrictions, using terms for alopecias and sleep disturbances. A total of 474 articles were identified; ...

Traditionally, hormonal acne treatment has been associated with systemic medications, which carry various restrictions and side effects. However, the development of topical antiandrogens is opening new possibilities for targeting the disease's pathogenesis directly within the skin. The focus is on clascoterone 1%, the first FDA-approved drug in this class, as well as on experimental topical formulations of spironolactone and flutamide. In our new editorial note, we examine the rationale behind this approach, the results of key clinical trials, and the role of topical hormonal therapy in modern treatment protocols. We explore the efficacy of these new formulas and identify which safety questions still require further investigation. Full breakdown — in our editorial note.

Have you ever noticed that wounds heal differently depending on the time of year? Clinical statistics confirm that regeneration is faster in spring and autumn than in the height of summer or the depths of winter. But why does the skin react to temperature this way? A recent study using mouse models and skin tissue-engineered equivalents has revealed the secret of "ideal cold." It turns out that local cooling to 20°C acts as a metabolic switch. It activates the ELOVL4 enzyme, which triggers the synthesis of valuable omega-3 fatty acids — DHA and EPA — directly at the site of injury. These molecules suppress excessive inflammation (TNFα) and literally "push" the wound from a prolonged inflammatory phase into the phase of active cell division and vessel growth. Scientists have identified the precise temperature window that accelerates epithelialization and improves tissue recovery. Research breakdown and practical highlights — in our editorial note.

Patients with keloids and hypertrophic scars often present with lower 25(OH)D levels, and vitamin D is widely discussed for its role in inflammation and wound healing. However, observational studies don't answer the key question: is this a cause, a consequence, or a result of confounding factors? In a 2025 study published in the Journal of Cosmetic Dermatology, researchers used two-sample Mendelian randomization to assess the causal relationship between serum 25(OH)D and the risk of keloids and hypertrophic scars. The findings may shift expectations regarding vitamin D supplementation as a preventive strategy for pathological scarring. Research breakdown and practical insights — in our editorial note.

For several years, exosomes have been recognized as one of the most promising directions in aesthetic medicine. Today, they are viewed as a versatile “cell-free” tool for skin rejuvenation, used in a variety of formats – from topical serums to complex microneedling protocols. This interest is biologically justified: exosomes are nanovesicles that carry proteins, lipids, and nucleic acids and directly participate in inflammation, extracellular matrix remodeling, and tissue regeneration. In early 2026, Cureus published a systematic review that analyzed all human clinical studies available by late 2025 that used exosome-based products for aesthetic skin rejuvenation. The review discusses exosome sources, treatment formats (topical use, combinations with microneedling and energy-based technologies, other options), measured endpoints, and the safety profile. At the same time, the authors emphasize a key issue: the evidence base remains fragmented, most studies are small, heterogeneous, and short-term. Exosomes look promising, but it is ...

Acne scars are notoriously difficult to treat, requiring deep dermal action while minimizing the risk of complications and downtime, especially in patients with darker skin types. A recent study in the Journal of Cosmetic Dermatology describes Synchronous Ultrasound Parallel Beam (SUPERB) technology: high-intensity, high-frequency, non-focused ultrasound creates multiple "cylindrical" zones of controlled thermal injury (approx. 60–70°C) in the mid-dermis. The epidermis is preserved through integrated cooling and real-time skin temperature monitoring. The authors retrospectively evaluated the results of a single treatment for acne scars: 3D analysis showed an average reduction in depression volume of 23–27%, with moderate pain and no reported adverse events. Full study breakdown and practical insights are provided in our editorial note.

Keloid scars remain one of the most challenging problems in aesthetic medicine due to their tendency for continuous growth and high recurrence rates. Traditionally, they have been viewed as a result of excessive fibroblast activity, but a new study reveals an unexpected player in this process—melanin. The authors demonstrated that elevated pigment levels in keloid tissue are not merely a cosmetic defect but an active driver of fibrogenesis. Melanin triggers cellular iron overload and confers resistance to ferroptosis—a specific type of cell death that normally should limit scar overgrowth. The researchers identified a complex network of interactions between melanocytes and fibroblasts that sustains the pathological process. These findings pave the way for novel therapeutic approaches that target melanogenesis to control scar growth. Full breakdown in our editorial feature.

The skin's ability to recover without scarring is a unique feature of the intrauterine period that is lost after birth. Full-thickness injuries—whether surgical incisions, burns, or severe acne—often leave behind persistent deformities, pigmentation, and chronic inflammation. This process is influenced by genetic predisposition, health status, and environmental factors, meaning the skin often requires assistance. In search of agents that could bring postnatal healing closer to the intrauterine model, scientists have turned their attention to amniotic fluid. In 2025, a paper was published in the journal Annals of Case Reports describing the first cases of using purified amniotic fluid to heal facial abrasions and recalcitrant acne without scarring or pigmentation [1]. Read our editorial note to learn about the potential mechanisms of action of this biological resource, its clinical potential, and its limitations.

  Psoriasis is increasingly recognized as a systemic disease that extends beyond the skin and is closely intertwined with metabolic health. One of the most frequent and complex associations is the coexistence of psoriasis and type 2 diabetes mellitus (T2DM). A new review by Ouyang et al., published in Biomolecules & Biomedicine (2026), provides a detailed analysis of why these two conditions so often occur in the same patient and how understanding their shared mechanisms helps practitioners choose the right therapy [1].   Why they "meet": points of intersection in pathogenesis The link between psoriasis and diabetes is not merely a coincidence. Research shows they share common genetic "roots" (susceptibility loci) that influence both the immune system and metabolism. A crucial concept here is gene–environment interactions, which suggests that a person's genetic predisposition (their "baseline") manifests as a disease only under the influence of external factors such as diet, lifestyle, stress, or infections. For instance, a sp...

Atrophic post-acne scars are among the most common and emotionally challenging concerns in aesthetic practice. While topical treatments rarely affect established tissue defects, energy-based devices often rely on controlled injury, which inevitably triggers inflammation and increases the risk of post-inflammatory hyperpigmentation, particularly in patients with darker skin phototypes. Consequently, the search for effective and safe alternatives continues, with cellular therapy emerging as one of the most promising frontiers. In a pilot split-face study published in the Journal of Cosmetic Dermatology in 2025, researchers compared the efficacy and safety of three PRP sessions as a monotherapy versus a combination with autologous fibroblasts. One side of the face received PRP alone, while the other received a suspension of fibroblasts in PRP. Results were evaluated after 6 months using biometric assessment and ultrasound. Full research breakdown and practical insights in our editorial note.

It is time to stop viewing melasma as merely "excess pigment." Modern research shows it is a complex, multifactorial process involving not only melanocytes but also pathological vascular proliferation, chronic inflammation, and even disruptions in the skin's local immune status. This is why standard brightening regimens often yield only temporary results. Tranexamic acid has emerged as a breakthrough, working on three fronts: blocking melanocyte stimulation, calming the vascular component, and reducing inflammation. But which administration route is more effective and safer — tablets or cream? Iranian scientists conducted a randomized clinical trial to compare these approaches in real-world practice. The results were published in the Journal of Cosmetic Dermatology in July 2025. Research breakdown and practical insights — in our editorial note.

While rosacea is typically considered an adult condition (most common in ages 30–50), early onset is well-documented: classic clinical manifestations can appear as early as infancy. In children and adolescents, rosacea is frequently underdiagnosed, often mistaken for more common conditions, with a correct diagnosis sometimes taking months or even years. A key clinical takeaway: pediatric patients experience ocular manifestations more frequently than adults, and in about half of cases, these symptoms may precede skin lesions or occur in isolation. We explore how to recognize pediatric rosacea, its clinical distinctions, and the therapeutic and skincare options discussed in the latest review. Full details in our editorial note.

Hyaluronic acid (HA) is traditionally considered a key component of the dermis, yet its role in the epidermis is equally critical for skin health. In atopic dermatitis (AD), HA metabolism undergoes significant changes: instead of the usual long chains, short fragments predominate, which are less effective at retaining moisture and more actively promote inflammation. The imbalance between HA synthesis and degradation directly leads to epidermal barrier defects, dryness, and spongiosis—the characteristic edema seen during flare-ups. Understanding these mechanisms opens new perspectives on the use of topical and oral HA in the comprehensive management of patients with AD. Research breakdown and practical insights in our editorial note

  In daily practice, it is increasingly evident that skin and emotions are much more closely linked than previously assumed. Flare-ups of chronic dermatoses under stress, “reactive” sensitivity in anxious patients, and the impact of sleep quality on regeneration are all manifestations of the skin–brain axis at work. Against this background, neurocosmetics are no longer just a marketing category but a scientifically grounded approach that uses cutaneous pathways to support a person’s psychophysiological state. A recent review in Clinics in Dermatology analyzes the mechanisms behind this connection and the role of neurocosmetics in maintaining balance between the skin and the brain [1].   The skin as a neuroendocrine organ and the skin–brain axis The skin is a complex sensory organ with its own neuroendocrine system. Keratinocytes, melanocytes, and immune cells can synthesize and respond to beta-endorphins, dopamine, serotonin, substance P, and other mediators. Through a network of nerve endings and signaling molecules, a continuous...

Retinoids have long been a backbone for acne care and photoaging management, but the focus is shifting: it is not only about receptors and concentrations anymore. What happens on the skin surface and inside the follicle may matter too. A 2025 review suggests that the skin microbiome can participate in local vitamin A derivative metabolism: some microbes may increase the local pool of retinoic acid, while others may convert it back into less active forms. At the same time, “next‑generation retinoids” (such as RAR‑γ–selective agonists) and advanced delivery approaches (nanostructured lipid carriers, depot concepts, stimulus‑responsive gels) aim to reduce irritation and make outcomes more predictable. Practical take‑home: tolerability and results may depend on the molecule, the formulation, and the skin’s microbial context. Full breakdown and clinical takeaways in our editorial note.

Wrinkles are not only about photoaging and chronological time. Growing evidence suggests the skin microbiome is involved in molecular pathways that drive collagen and elastin degradation. With age, sebum levels and hydration decline, transepidermal water loss increases, and microbial composition shifts. These changes can sustain chronic inflammation and oxidative stress, activate signaling pathways that increase matrix metalloproteinase expression, and accelerate extracellular matrix breakdown. In this editorial note, we discuss how the microbiome is linked to MMP activity, why this can speed wrinkle formation, and what data exist on probiotics and postbiotics in the context of age-related skin changes. Complete analysis in our editorial note.

Hyaluronidase remains the key rescue option for overcorrection and vascular events that may occur after hyaluronic acid filler injections. Yet why is the clinical response so unpredictable? A 2025 study in the Journal of Cosmetic Dermatology suggests the answer lies mainly in filler architecture. Biphasic gels break down quickly at relatively low hyaluronidase doses, whereas monophasic fillers often require higher cumulative dosing and direct intralesional delivery into the implant. Another practical point is the enzyme’s short activity window in tissue, which appears to close sooner than many clinicians assume. We break down the key differences and the clinical takeaways for day-to-day practice.

We often explain acne in a simple way: more sebum at puberty, then bacteria and inflammation. But a 2025 review argues that acne can have an earlier “starting point” shaped by genetics. The key event may be a misstep in how sebaceous-gland precursor cells develop where the gland drains into the hair canal. If cells “choose the wrong path” or don’t move when they should, a comedone forms. Inflammation often comes later, as a response to the traffic jam already created inside the follicle. This framework helps clinicians explain why retinoids matter and why similar routines can lead to very different outcomes. Research takeaways and practice pearls — in our editorial note.

HIFU is most often associated with skin tightening. But what actually changes at the tissue level — and why do some patients describe the outcome as a “lift,” while others say their face looks “slimmer”? Until recently, that question didn’t have a clear, practical explanation. In a 2025 paper published in the Journal of Cosmetic Dermatology, the authors examine post-HIFU histologic changes at different target depths, correlate these findings with patient-reported outcomes, and arrive at a compelling answer. Please read the full breakdown in our editorial note.

Film-forming sprays (FFS) are rapidly gaining popularity in skin care and treatment. FFS is a liquid that, when sprayed onto the skin, forms a thin, transparent film. The base of FFS consists of polymers and solvents, with biologically active substances serving as the active ingredients. Polymers create a protective film on the skin's surface, helping to retain moisture and shield against direct contact with external irritants (bacteria, viruses, allergens, solid dust particles, etc.). The film also regulates the rate of release and delivery of active substances to the skin, providing a longer-lasting effect and reducing the frequency of application. This is especially important in the treatment of chronic skin diseases such as psoriasis and eczema, where prolonged and even application of medication is necessary. Our editorial note explores what FFS is and the new opportunities it presents.

  Cellulite is a problem familiar to many women. Its appearance is associated with changes in the subcutaneous fatty tissue: fat cells increase in size, forming bumps and indentations on the skin. These changes are caused by a complex interaction of various factors, including genetics, hormonal background, connective tissue structure, and microcirculation. As a result, fibrous septa are formed, which squeeze the fat lobes and worsen the appearance of the skin. There are various methods to fight cellulite — from cosmetic creams to invasive surgical procedures, but there is no ideal solution yet. A group of dermatologists from Brazil has proposed a new approach that combines a minimally invasive subcision technique with hyaluronic acid (HA). The essence of subcision is the gentle rupture of the fibrous septa that compresses the adipose tissue. This allows the fat lobes to be released and improves the appearance of the skin. However, simply tearing the septae is not enough — a void is created in its place, which needs to be filled. T...

Mycosporin-like amino acids (MAA) represent a promising class of natural bioactive compounds with a wide range of applications in the cosmetic industry. Their efficacy in UV protection and their antioxidant and anti-inflammatory properties make MAAs an attractive alternative to synthetic UV filters, especially considering their high safety. Our new editorial is dedicated to these fascinating natural compounds.

Botulinum toxin injections are a popular procedure, but they can have unexpected consequences. In our new post, we will describe a clinical case in which the misuse of atropine to treat diplopia following botulinum therapy led to serious complications. We will also discuss how to avoid such mistakes and what precautions should be taken to maintain eye health.

Aging is a vast field of research in which scientists actively try to unravel the causes and mechanisms of cell, tissue, and organ degradation over time. Various theories of aging exist, such as genetic, stochastic, telomere, and mitochondrial theories, each offering distinctive explanations for the physiological changes observed in organisms as they age. In this post, we will consider a new view of aging based on the autodigestion of body tissues under the action of digestive enzymes.

Bacterial resistance to antibiotics is a significant challenge in modern healthcare. The constant search for new treatments has led to the development of innovative phototherapy using metal-organic frameworks (MOFs). The latest technology offers effective and safe phototherapy dressings for treating infected wounds. Phototherapy dressings are safe, effective, and easy to use and can be an essential tool in the fight against infections. Our latest editorial describes this new technology and why it is receiving so much attention.

Production technologies and mechanisms of action Modern technologies have made it possible to expand the functionality of textiles significantly. The microencapsulation method, for example, is used to encapsulate active substances such as hyaluronic acid or plant extracts into capsules released by friction or temperature. This technology is used in the Skintex® product line of moisturizing and skin care products. The chemical grafting method allows molecules of active ingredients, such as probiotics or vitamins, to be bound to textile fibers. Devan Biotech's fabrics use this approach, which helps maintain the balance of the skin's microbiome. Studies have shown that probiotics in these fabrics stimulate the growth of beneficial microorganisms such as Staphylococcus epidermidis and inhibit the growth of pathogenic bacteria, including Staphylococcus aureus [1, 2]. Antimicrobial biotextiles enriched with silver or zinc ions act by interacting with bacterial membranes, disrupting their structure. This leads to the inhibition of metabo...

Modern technology continues transforming healthcare and appearance care, and artificial intelligence (AI) has become a key tool in this evolution. Cosmetology, dermatology, and aesthetic medicine already use AI to diagnose, personalize treatments, and optimize processes. Let's examine the current advances, implementation examples, and prospects for AI in these fields. Our new editorial provides more details and examples.

Botulinum toxin A (BTA) has long established itself as an effective agent in aesthetic medicine and in treating dermatologic diseases. BTA has demonstrated its therapeutic properties in treating rosacea, acne, and alopecia and is also used to improve post-surgical scarring. Recently, atopic dermatitis has been added to the list of potential indications for using BTA, which opens new horizons in treating this congenital dermatosis. A study published in the Journal of Clinical and Aesthetic Dermatology in 2020 was an essential step in this direction. It is described in our post.

The role of the skin microbiome in promoting human health is becoming increasingly clear, and more details about its functions are emerging every year. Skin commensals modulate mucosal immune defenses and directly counteract pathogens, but their contribution to the physical integrity of the skin is poorly understood. A study by Zheng Y. et al. published in the Cell Host & Microbiome in 2022 showed that the common skin commensal Staphylococcus epidermidis contributes to skin barrier integrity in a very unusual way. This is the subject of our new post.

  The role of pH for skin health Enzymes of the stratum corneum, such as serine proteases and ceramidases, are active at specific pH values. These enzymes regulate the processes of keratinization and exfoliation, which promote skin renewal and maintain skin smoothness and elasticity [1]. pH also affects the skin microbiome's activity, including beneficial bacteria such as Staphylococcus epidermidis and Cutibacterium acnes. A slightly acidic environment prevents the overgrowth of pathogens such as Staphylococcus aureus, which can cause inflammatory diseases, including atopic dermatitis and acne [2].   Mechanisms of skin pH maintenance The skin has its mechanisms for maintaining acidity. These include: Free fatty acids in the hydrolipid mantle are formed by the breakdown of sebum triglycerides by enzymes of bacteria living in the ducts of the sebaceous glands. Production of sweat containing lactic acid and amino acids. Some of these substances remain part of the hydrolipidic mantle, while the stratum corneum absorbs others. Activat...

Vitiligo is a chronic skin disease characterized by loss of pigmentation due to the destruction of melanocytes. It is believed that the key role in the development of vitiligo is played by an autoimmune mechanism in which T-cells and cytokines are activated, causing the death of melanocytes. None of the currently known treatments for vitiligo provides complete and long-term restoration of pigmentation. With the advent of topical Janus kinase inhibitors, there is hope for recovery in vitiligo patients. This is discussed in our new post.

MicroRNA therapy, which emerged as an experimental treatment in the early 2000s, is based on regulating gene expression by interacting small RNAs with microRNA targets. This approach has already been used in treating chronic skin ulcers and hypertrophic scars and, in recent years, has been actively investigated in the context of acne. Our post describes how close we came to putting this method into practice.

Pilonidal disease is an inflammatory condition involving the formation of cysts or fistulas in the area of the intergluteal cleft due to inflammation of the hair follicles. It is often accompanied by pain and infection and may require surgical intervention. Standard therapy, consisting of hygiene, special creams, and mechanical depilation, can reduce the severity of the disease but cure it completely. The hope for patients has become laser hair removal. How it helps in solving this problem is described in our new post.

Rosacea is a chronic inflammatory skin disease that develops due to dysregulation of the microcirculation in the midface. The clinical manifestations of rosacea are erythema and a progressive inflammatory rash. Despite its prevalence (according to various estimates, rosacea affects up to 22% of the population), this dermatosis still needs to be fully understood, and standard treatments are only sometimes effective. Research in recent years has drawn attention to tranexamic acid, known for its effects on melasma and post-inflammatory hyperpigmentation, to combat rosacea symptoms. These studies are described in our new post.

Trichotillomania (TTM) is a psychiatric disorder characterized by frequent, recurrent, and irresistible urges to pull hair from one's head, eyebrows, or other areas of the body. Cognitive behavioral therapy and antidepressants have traditionally been used to treat this disorder, but these treatments are not always successful. In recent years, research has emerged that looks at the use of injectable botulinum therapy in TTM patients. For details, see our new post.

Retinoids such as retinol and retinoic acid are widely used in anti-aging therapy because they stimulate cell renewal, collagen synthesis, and wrinkle elimination. However, their use is limited due to pronounced adverse reactions such as redness, dryness, flaking, and skin irritation, which are especially noticeable in people with sensitive skin. The search for safe alternatives with retinol-like effects remains an urgent task. Promising retinol substitutes include bakuchiol and Vigna aconitifolia bean extract. More about the retinol plant analogs study is in our post.

Why does hair turn gray, and can it be stopped? A new study has discovered a mysterious process that leads to hair color loss: when a person reaches a certain age, the melanocyte progenitor stem cells responsible for pigmentation get “stuck” in a transitional state and lose their function. What if this could be reversed? Scientists believe that by unlocking the secret of these “chameleon cells,” we can understand why we are graying and learn how to prevent graying. For details see our new post.

A balanced skin microbiome is one of the guarantors of skin health. Changes in the species composition of the microbiome may be one of the links in the pathogenesis of skin diseases or a consequence of them. For this reason, the skin microbiome is considered by many researchers and clinicians as one of the therapeutic targets that can be used to improve the health and aesthetic appeal of the skin. In our new post, we will discuss the effects of blue light on the skin microbiome composition of atopic patients and the prospects of its application for phototherapy of atopic dermatitis.

Green hair color indicates not only the boldness of the personality. In some cases, green hair coloration is a symptom of a disease called chlorotrichosis. The first cases of chlorotrichosis were described in 1654. At that time, the owners of "green hair" were copper workers engaged in copper processing. Today's chlorotrichosis patients are hapless pool-goers. What does copper have to do with it? How to avoid chlorotrichosis? Find out in our post.

Due to the secretions of eccrine, apocrine, and sebaceous glands, the axillae provide a moist and nutrient-rich habitat for many microorganisms. The appearance of odorless sweat is caused by the biotransformation of naturally occurring odorless secretions into volatile odorous molecules. In our new post, you will learn how the underarm microbiome changes during laser hair removal and how this affects the severity of sweat odor.

Living in a multinational world, we see the beauty of the human image in all its diversity. The combination of phenotypic traits endows each ethnic group with recognizable appearance features. As research shows, this also hides the skin's significant structural and functional features. Is it true that dark skin has more pronounced barrier properties, while light skin is drier and more fragile? This question has seriously interested scientists from Switzerland.

Hirsutism is an excessive growth of hair of the male type in women: lightly colored pubes transform into thick and pigmented terminal hairs above the upper lip, on the chin, in the sideburns, as well as on larger areas of the body — the lower abdomen, inner thighs, nipples, sternum, sacrum, and shoulders. Pathological hair loss is caused by diseases associated with hyperandrogenism or increased sensitivity of androgen receptors, which significantly complicates the long-term elimination of unwanted hair. Will the laser cope with this target? What does the effectiveness of laser hair removal for hirsutism depend on? You will find the answers in our new post.